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Real-Time Polymerase Chain Reaction-Based Detection and Quantification of Hepatitis B Virus DNA
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[HIV and hepatitis B virus co-infection: prevalence and risk factors]

Milta Gomes de Souza1, Afonso Dinis Costa Passos, Alcyone Artioli Machado

  • 1Departamento de Medicina Social, Faculdade de Medicina de Ribeirão Preto, Universidade de São Paulo, Ribeirão Preto, SP.

Revista Da Sociedade Brasileira De Medicina Tropical
|September 14, 2004
PubMed

Insights

This study found a high prevalence of hepatitis B virus (HBV) markers in HIV patients. Key risk factors included age, education, jaundice history, incarceration, homosexual partnerships, and hepatitis C virus (HCV) co-infection.

Area of Science:

  • Infectious Diseases
  • Hepatology
  • Virology

Context:

  • Human immunodeficiency virus (HIV) infection significantly impacts immune function.
  • Co-infection with hepatitis B virus (HBV) and hepatitis C virus (HCV) is common in HIV-positive individuals.
  • Understanding HBV prevalence and risk factors in this population is crucial for clinical management.

Purpose:

  • To determine the prevalence of hepatitis B virus (HBV) infection markers in HIV-infected patients.
  • To identify potential risk factors associated with HBV infection in this cohort.
  • To assess the rate of HBV/HCV co-infection.

Summary:

  • A study of 401 HIV patients revealed a 40.9% prevalence of HBV markers.
  • Significant risk factors for HBV included age, education, jaundice history, imprisonment, homosexual partnerships, and HCV co-infection.
  • Hepatitis B surface antigen (HBsAg) was present in 8.5%, total anti-HBcAg in 39.7%, and anti-HBsAg in 5.5%.

Impact:

  • Findings highlight the substantial burden of HBV in HIV-positive individuals.
  • Identified risk factors can inform targeted screening and prevention strategies.
  • The high rate of HBV/HCV co-infection (20.4%) underscores the need for integrated viral hepatitis management in HIV care.

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