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Developmental regression in autism spectrum disorders.

Sally J Rogers1

  • 1University of California, Davis Medical Center, M.I.N.D. Institute, Davis, California 95817, USA. Sally.rogers@ucdmc.ucdavis.edu

Mental Retardation and Developmental Disabilities Research Reviews
|September 14, 2004
PubMed
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Developmental regression in autism, while puzzling, often follows subtle early differences. This regression may indicate greater impairment and does not predict better outcomes compared to non-regressive autism.

Area of Science:

  • Neurodevelopmental Disorders
  • Pediatric Neurology
  • Developmental Psychology

Background:

  • Developmental regression is a perplexing characteristic of autism spectrum disorder (ASD).
  • Parental reports and home videos validate regression, but subtle early differences often precede it.
  • Regression in ASD is more frequent than in other developmental conditions.

Purpose of the Study:

  • To investigate the developmental trajectory and outcomes of children with autism experiencing developmental regression.
  • To compare the characteristics and prognosis of regressive versus non-regressive autism.
  • To explore the relationship between regression and other neurodevelopmental disorders.

Main Methods:

  • Analysis of parental reports and home video data to validate regression.

Related Experiment Videos

  • Comparison of developmental outcomes and behavioral phenotypes between regressive and non-regressive autism groups.
  • Review of literature on other conditions exhibiting early regression, including autism, blindness, childhood disintegrative disorder, Rett syndrome, and Landau-Kleffner syndrome.

    • Main Results:

    • Children with regressive autism often show subtle prior developmental differences.
    • Regression does not appear to predict better skill recovery or outcomes; the regressive group may show greater impairment.
    • Behavioral phenotypes are similar between regressive and non-regressive autism groups.

    Conclusions:

    • Developmental regression in autism is a complex phenomenon, often preceded by subtle differences, and associated with potentially greater impairment.
    • The regressive course in autism does not confer a better prognosis.
    • Autism is the most common condition featuring developmental regression, which also occurs in other neurological and genetic disorders.