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Oral sumatriptan-induced myocardial infarction
1Pitt County Memorial Hospital, East Carolina University, Greenville, NC 27850, USA. hackj@mail.ecu.edu
Journal of Toxicology. Clinical Toxicology
|September 15, 2004
Summary
A case report details a myocardial infarction in a woman without cardiac risk factors after taking oral sumatriptan. This highlights potential cardiac risks of sumatriptan even in low-risk patients.
Area of Science:
- Cardiology
- Neurology
- Pharmacology
Background:
- Sumatriptan, a medication for migraines and vascular headaches, has been available in the U.S. since 1993.
- Known cardiac side effects, such as chest pain, affect 3-8% of patients with pre-existing cardiac risk factors.
Observation:
- A 45-year-old woman with no prior cardiac history experienced a myocardial infarction (MI).
- The MI occurred subsequent to her monthly dose of oral sumatriptan.
Findings:
- Cardiac catheterization revealed normal heart function but identified a significant stenosis (60-70%) in a septal perforator artery.
- Laboratory tests for cardiac risk factors were within normal limits.
Implications:
- This case suggests that oral sumatriptan may precipitate myocardial infarction in individuals without apparent cardiac risk factors.
- Clinicians should consider the potential for serious cardiac events, including MI, even in sumatriptan users without traditional cardiac risk factors.
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