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Updated: Aug 22, 2026
Systems Biology of Metabolic Regulation by Estrogen Receptor Signaling in Breast Cancer
Published on: March 17, 2016
[Expression and significance of estrogen receptor isoforms in the development of human breast carcinoma]
Shu Wang1, Shan Wang, Jia-qing Zhang
1Breast Disease Center, Peking University People's Hospital, Beijing 100044, China.
Objective:
To investigate the estrogen receptors (ER)alpha and ERbeta expression and their relationship with clinicopathological parameters in human breast carcinoma.
Methods:
Samples were obtained from 30 breast carcinoma, reverse transcriptase polymerase chain reaction was used to measure the expression of ERalpha and ERbeta mRNA.
Results:
ERalpha mRNA level was up-regulated in breast carcinoma tissue compared with adjacent normal tissue (t = 7.399, P < 0.01) while down-regulated in ERbeta. The relative ratio of ERalpha and ERbeta was decreased in normal tissue vs. carcinoma (t = 6.385, P < 0.01), in patients with lymph node metastasis vs. those without lymph node metastasis (t = 2.602, P < 0.05), in late stage carcinoma vs. early stage (t = 3.754, P < 0.05).
Conclusion:
ERalpha and ERbeta play divergent role in the development of human breast carcinoma.
