Effect of plasticization on heparin release from biodegradable matrices

¹School of Materials Engineering, Nanyang Technological University, N4.1-1-30 Nanyang Avenue, Singapore 639798, Singapore.

|September 15, 2004

Summary

Plasticizers affect heparin release from polymer films differently based on polymer type. Poly-L-lactide (PLLA) films showed reduced burst release, while poly-L-lactide-co-glycolide (PLLGA) films were largely unaffected by plasticizers.

Area of Science:

Biomaterials Science
Polymer Chemistry
Drug Delivery Systems

Background:

Heparin is a crucial anticoagulant drug.
Polymer films are investigated for controlled drug release applications.
Understanding polymer-drug interactions is key for effective delivery systems.

Purpose of the Study:

To investigate the effect of polyethylene glycol (PEG) plasticizer on heparin release from poly-L-lactide (PLLA), poly-L-lactide-co-glycolide (PLLGA), and poly-DL-lactide-co-glycolide (PLGA) films.
To analyze the influence of polymer composition and plasticizer on drug release kinetics and degradation.
To correlate release profiles with polymer properties like hydrophilicity and crystallinity.

Main Methods:

Fabrication of heparin-loaded polymer films using PLLA, PLLGA, and PLGA.
Incorporation of polyethylene glycol (PEG) as a plasticizer.
In vitro release studies to determine heparin release profiles.
Analysis of degradation kinetics and polymer properties.

Main Results:

Heparin release generally followed a burst, diffusion, and degradation-controlled pattern.
PEG accelerated degradation in all tested polymers.
PEG significantly altered release profiles: reduced burst and accelerated diffusion in PLLA, but had minimal effect on PLLGA 80/20.
Observed differences were attributed to polymer hydrophilicity and crystallinity.

Conclusions:

Plasticizer effectiveness in modulating heparin release is polymer-dependent.
PLLA and PLLGA 80/20 exhibit distinct responses to PEG, highlighting the importance of polymer selection for drug delivery.
Hydrophilicity and crystallinity are critical factors influencing drug release from biodegradable polymer matrices.

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Effect of plasticization on heparin release from biodegradable matrices

Area of Science:

Background:

Purpose of the Study:

Main Methods:

Main Results:

Conclusions:

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