Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Vascular endothelial growth factor - basic science and its clinical implications.

Peter Celec1, Yoshikazu Yonemitsu

  • 1Institute of Pathophysiology, Faculty of Medicine, Comenius University, Bratislava, Slovakia; Department of Molecular Biology, Faculty of Natural Sciences, Comenius University, Bratislava, Slovakia.

Pathophysiology : the Official Journal of the International Society for Pathophysiology
|September 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Formyl peptide receptor 1 agonism selectively suppresses mitochondria-driven neutrophil extracellular trap formation while preserving antibacterial immunity.

Molecular medicine (Cambridge, Mass.)·2026
Same author

Neutrophil extracellular traps in the animal model of adenine-induced chronic kidney disease.

PloS one·2026
Same author

Cisplatin - induced peripheral neuropathy and biomarkers of gut microbial translocation in testicular germ cell tumor survivors.

Frontiers in immunology·2026
Same author

Neonatal testosterone exposure modulates exploration and object avoidance without exacerbating autism-like behavior in Shank3b-deficient mice.

Hormones and behavior·2026
Same author

Novel NK cell-like phenotype expressing CCR5 and its ligands elicits tumor-specific acquired immunity to carcinomatous peritonitis via host NK-derived IFN-γ.

Journal for immunotherapy of cancer·2026
Same author

Extracellular heme:DNA complexes promote oxidative stress and inflammation during lupus-associated hemolysis.

Proceedings of the National Academy of Sciences of the United States of America·2026
Same journal

Revisiting Atopy: The IgE-Dependent Amplification Loop as a Forgotten Driver of Atopic Dermatitis.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same journal

Pulmonary Squamous Cell Carcinoma Dissemination Through Air Spaces (STAS): Clinicopathologic Findings in Different Tumor Origins.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same journal

Oxidative and Nitrosative Stress in Atopic Dermatitis and Depression: Similarities in Biomarkers and Pathophysiological Mechanisms.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same journal

NG2 Glia and Cellular Crosstalk in Health and Disease: Focus on Spinal Cord Injury.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same journal

Intracellular Ionic Remodeling During Fetal Development of Hereditary Cardiomyopathy of the Hamster.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
Same journal

From Glycocalyx Shedding to Microvascular Collapse in Sepsis: Endothelial Pathophysiology, Organ Dysfunction, and Mechanistic Biomarkers.

Pathophysiology : the official journal of the International Society for Pathophysiology·2026
See all related articles

Vascular endothelial growth factor (VEGF) is key for new blood vessel formation. Research reveals its dual role in treating ischemic diseases and inhibiting cancer, offering new therapeutic avenues.

Area of Science:

  • Biomedicine
  • Molecular Biology
  • Pathophysiology

Background:

  • Vascular endothelial growth factor (VEGF) is a critical signaling molecule regulating angiogenesis (new blood vessel formation).
  • Recent studies have elucidated novel molecular mechanisms underlying VEGF signaling pathways.
  • VEGF plays a significant role in various physiological and pathophysiological processes.

Purpose of the Study:

  • To summarize recent findings on VEGF-related studies.
  • To provide a theoretical resource for future research on VEGF's role in disease.
  • To explore therapeutic interventions involving VEGF in clinical biomedicine.

Main Methods:

  • Review of recent scientific literature on VEGF.
  • Analysis of molecular mechanisms of VEGF signaling.

Related Experiment Videos

  • Synthesis of theoretical frameworks for future research.

    • Main Results:

    • VEGF is central to angiogenesis.
    • VEGF signaling pathways have complex molecular mechanisms.
    • VEGF has therapeutic potential in ischemic diseases (e.g., coronary artery disease) and cancer treatment.
    • VEGF is implicated in other physiological and pathophysiological processes.

    Conclusions:

    • VEGF is a pivotal factor in angiogenesis with significant implications for disease.
    • Targeting VEGF offers promising therapeutic strategies for both ischemic conditions and cancer.
    • Further research into VEGF's multifaceted roles is crucial for advancing clinical biomedicine.