Related Experiment Video
Updated: Aug 22, 2026
Isolation and Identification of Limbal Niche Cells
Published on: October 27, 2023
Langerhans cell histiocytosis presenting as a limbal nodule in an adult patient
Tishu Saxena1, Krishna Kumar, Seema Sen
1Cornea and Refractive Surgery Services, Rajendra Prasad Centre for Ophthalmic Sciences, All India Institute of Medical Sciences, New Delhi 110029, India.
Purpose:
To report a case of Langerhans cell histiocytosis presenting as a limbal nodule.
Design:
Observational case report.
Method:
A 26-year-old man presented with a superior limbal mass. On clinical examination, an infiltrative/neoplastic lesion was suspected, and a differential diagnosis of limbal amyloidosis, limbal fibrous histiocytoma, lymphoma, and juvenile xanthogranuloma was made. There was no other associated ocular or systemic abnormality. An excision biopsy was performed.
Results:
The histopathology and immunohistochemical staining examination established the diagnosis of limbal Langerhans cell histiocytosis.
Conclusion:
To the best of our knowledge, this is an unusual presentation of Langerhans cell histiocytosis, and although rare, Langerhans cell histiocytosis should be included in the differential diagnosis of a limbal mass.
