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Mycoplasma genitalium urethritis in men
Satoshi Ishihara1, Mitsuru Yasuda, Shin-ichi Ito
1Department of Urology, Gifu University School of Medicine, Gifu, Japan. s-ishi@cc.gifu-u.ac.jp
International Journal of Antimicrobial Agents
|September 15, 2004
Summary
Mycoplasma genitalium is a likely cause of non-gonococcal urethritis (NGU), especially non-chlamydial NGU. Eradicating this bacteria is crucial for managing persistent NGU, though optimal treatment requires further study.
Area of Science:
- Urology
- Microbiology
- Infectious Diseases
Background:
- Mycoplasma genitalium was first identified in patients with non-gonococcal urethritis (NGU).
- This bacterium has been increasingly detected in NGU cases, particularly non-chlamydial NGU.
- Its persistence in the urethra correlates with persistent or recurrent NGU post-treatment.
Purpose of the Study:
- To evaluate the role of Mycoplasma genitalium as a pathogen in NGU.
- To review the clinical significance of M. genitalium in NGU and its treatment.
- To highlight the need for effective chemotherapy to eradicate M. genitalium in NGU management.
Main Methods:
- Literature review of studies investigating Mycoplasma genitalium in NGU.
- Analysis of prevalence data in patients with and without urethritis.
- Assessment of treatment outcomes and bacterial persistence.
Main Results:
- Mycoplasma genitalium is detected significantly more often in NGU patients than in controls.
- Prevalence in non-chlamydial NGU ranges from 18% to 46%.
- M. genitalium persistence post-treatment is linked to persistent or recurrent NGU.
Conclusions:
- Evidence supports Mycoplasma genitalium as a causative agent of NGU.
- Eradication of M. genitalium is essential for managing M. genitalium-positive NGU.
- Further research is needed to determine optimal antimicrobial chemotherapy for M. genitalium NGU.