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Related Experiment Videos

Bupropion for smoking cessation: a randomized trial.

Joel A Simon1, Carol Duncan, Timothy P Carmody

  • 1General Internal Medicine Section, Medical Service, San Francisco Veterans Affairs Medical Center, San Francisco, CA 94121, USA. jasimon@itsa.ucsf.edu

Archives of Internal Medicine
|September 15, 2004
PubMed
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Adding bupropion hydrochloride to nicotine replacement therapy and counseling did not significantly improve smoking cessation rates in a randomized trial. Long-term quit rates were similar between bupropion and placebo groups.

Area of Science:

  • Clinical Trials
  • Pharmacology
  • Public Health

Background:

  • Bupropion hydrochloride is a recommended smoking cessation aid.
  • Limited clinical trials exist on bupropion's efficacy for smoking cessation.

Purpose of the Study:

  • To evaluate the efficacy of bupropion hydrochloride in smoking cessation.
  • To compare quit rates between bupropion and placebo groups when combined with NRT and counseling.

Main Methods:

  • A randomized, blinded trial involving 244 current smokers.
  • Participants received a 7-week course of bupropion or placebo.
  • All participants received transdermal nicotine replacement therapy and cognitive-behavioral counseling.

Main Results:

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  • A trend towards higher quit rates was observed during treatment with bupropion versus placebo.
  • This trend did not persist at 6 months or 1 year follow-up.
  • Biochemically validated 1-year quit rates were 19% for bupropion and 24% for placebo.

Conclusions:

  • A 7-week course of bupropion did not significantly increase smoking cessation rates.
  • The addition of bupropion to NRT and counseling showed no long-term benefit.
  • Findings suggest bupropion may not enhance cessation outcomes in this combined treatment approach.