Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Inspiratory muscle weakness in diastolic dysfunction.

Marc H Lavietes1, Christine M Gerula, Kristin G Fless

  • 1University Hospital #I354, 100 Bergen St, Newark, NJ 07103, USA. lavietmh@umdnj.edu

Chest
|September 15, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Electrocardiographic changes in transgender patients on gender-affirming hormone replacement therapy.

Journal of electrocardiology·2025
Same author

Echocardiographic Updates in the Assessment of Cardiomyopathy.

Current cardiology reports·2025
Same author

Accountable Care's Reach in Medicare.

The New England journal of medicine·2022
Same author

Factors Associated with Disparities in Appropriate Statin Therapy in an Outpatient Inner City Population.

Healthcare (Basel, Switzerland)·2020
Same author

Association of Dioxin and Dioxin-like Congeners With Hypertension.

Federal practitioner : for the health care professionals of the VA, DoD, and PHS·2019
Same author

Cryptogenic Stroke: To Close a Patent Foramen Ovale or Not to Close?

Journal of central nervous system disease·2018

Patients with diastolic dysfunction (DD) experience inspiratory muscle weakness and a rapid, shallow breathing pattern during exercise, leading to increased dyspnea. This study confirms these findings, highlighting a significant difference compared to healthy individuals.

Area of Science:

  • Cardiology
  • Pulmonology
  • Exercise Physiology

Background:

  • Respiratory muscle weakness is documented in systolic heart failure.
  • The presence of similar findings in diastolic dysfunction (DD) is not well-established.
  • Investigating respiratory mechanics in DD is crucial for understanding patient limitations.

Purpose of the Study:

  • To determine if patients with diastolic dysfunction (DD) exhibit inspiratory muscle weakness.
  • To assess if DD patients experience dyspnea and tachypnea during exercise.
  • To compare respiratory parameters in DD patients versus healthy controls.

Main Methods:

  • 14 patients with confirmed DD and 7 matched controls underwent pulmonary function tests.
  • Maximal inspiratory pressure (Pimax) and handgrip strength (Hgr) were measured.

Related Experiment Videos

  • Graded exercise tests monitored ventilation, gas exchange, and heart rate, with dyspnea rated on the Borg scale.

    • Main Results:

    • Patients with DD showed significantly diminished Pimax compared to controls (p=0.013).
    • DD patients reported higher dyspnea scores (2.6 vs 0.5 Borg units) at submaximal exercise.
    • A rapid, shallow breathing pattern was observed in DD patients during exercise.

    Conclusions:

    • Diastolic dysfunction is associated with reduced inspiratory muscle strength (Pimax).
    • Patients with DD develop a rapid, shallow breathing pattern during exertion.
    • Dyspnea occurs at lower exercise workloads in individuals with DD.