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Basophil Activation Test for Investigation of IgE-Mediated Mechanisms in Drug Hypersensitivity
Published on: September 16, 2011
Aminophylline hypersensitivity apparently due to ethylenediamine
1Section of General Internal Medicine, College of Medicine, University of Illinois, Chicago.
Annals of Emergency Medicine
|March 1, 1992
Summary
Ethylenediamine, a component of aminophylline, can cause delayed allergic reactions in asthma patients. This case highlights the importance of considering ethylenediamine as a potential cause of hypersensitivity, confirmed by patch testing.
Area of Science:
- Allergy and Immunology
- Pulmonology
- Pharmacology
Background:
- Asthma management often involves multiple medications.
- Aminophylline is a common bronchodilator used in acute asthma exacerbations.
- Allergic reactions can complicate asthma treatment.
Observation:
- A 46-year-old woman experienced an allergic reaction after receiving parenteral aminophylline.
- The reaction was suspected to be a delayed hypersensitivity response.
- Ethylenediamine, a component of aminophylline, was investigated as the potential cause.
Findings:
- Patch testing for ethylenediamine was positive in the patient.
- This confirmed ethylenediamine as the etiologic agent for the hypersensitivity reaction.
- The case underscores a less commonly suspected cause of allergic reactions in asthma patients.
Implications:
- Clinicians should consider ethylenediamine as a potential allergen in patients with asthma on aminophylline.
- Positive patch testing can confirm ethylenediamine hypersensitivity.
- Awareness of this adverse drug reaction can improve patient safety and treatment strategies.
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