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Updated: Aug 19, 2026

High-throughput Screening for Broad-spectrum Chemical Inhibitors of RNA Viruses
Published on: May 5, 2014
Potential screening assay for undetectable viruses on the basis of their capacity to induce alpha interferon
Barbara Schmidt1, Brittany Ashlock, Frank Neipel
1Department of Medicine, Division of Hematology/Oncology, University of California School of Medicine, San Francisco, CA 94143-1270, USA.
Abstract:
High interferon production by plasmacytoid dendritic cells (PDC) was unexpectedly noted after their coculture with CD4(+) cells from a healthy donor whose cells subsequently showed human herpesvirus type 6 and 7 infections. This release of interferon was not observed with uninfected normal CD4(+) cells. Induction of PDC interferon production could help screen for covert virus infections.
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