Related Experiment Video

Updated: Aug 15, 2026

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry
08:07

Identification of Inositol Phosphate or Phosphoinositide Interacting Proteins by Affinity Chromatography Coupled to Western Blot or Mass Spectrometry

Published on: July 26, 2019

Elevation of myoinositol is associated with disease containment in progressive multifocal leukoencephalopathy

Rachel Katz-Brull1, Robert E Lenkinski, Renaud A Du Pasquier

  • 1Department of Radiology, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA.

Neurology
|September 15, 2004
PubMed

Insights

Prognostic factors for progressive multifocal leukoencephalopathy (PML) were identified. Survivors had higher glial markers and detected JC virus-specific T lymphocytes, suggesting inflammation limits disease progression.

Area of Science:

  • Neuroimaging
  • Immunology
  • Virology

Background:

  • Progressive multifocal leukoencephalopathy (PML) is a serious demyelinating disease.
  • Identifying prognostic factors is crucial for managing PML patients.

Purpose of the Study:

  • To investigate prognostic factors influencing disease evolution in PML.
  • To correlate imaging and immunological markers with PML outcomes.

Main Methods:

  • Utilized magnetic resonance imaging (MRI) and 1H-MR spectroscopy.
  • Conducted immunologic and virologic studies, including T-lymphocyte detection.
  • Compared markers in patients who survived versus those whose disease progressed.

Main Results:

  • PML survivors showed a twofold higher ratio of myoinositol (glial marker) to creatine in acute lesions.
  • JC virus-specific cytotoxic T lymphocytes were exclusively found in the blood of PML survivors.

Conclusions:

  • Elevated glial markers and the presence of JC virus-specific T lymphocytes are associated with better outcomes in PML.
  • Inflammation appears to play a protective role in limiting PML disease progression.

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