Related Experiment Videos
Intrathecal morphine for off-pump coronary artery bypass grafting
Samuel Metz1, Nanette Schwann, Wael Hassanein
1Department of Anesthesiology, Drexel University College of Medicine, Philadelphia, PA, USA. Samuel.Metz@Drexel.edu
Journal of Cardiothoracic and Vascular Anesthesia
|September 15, 2004
Summary
Preinduction intrathecal morphine use is linked to a high rate of intraoperative extubation in patients undergoing off-pump coronary artery bypass grafting. Continuous respiratory monitoring is recommended to manage potential delayed respiratory depression.
Area of Science:
- Anesthesiology
- Cardiothoracic Surgery
- Pharmacology
Background:
- Off-pump coronary artery bypass grafting (OPCAB) requires careful anesthetic management.
- Intrathecal morphine is an option for perioperative analgesia.
Purpose of the Study:
- To evaluate the association between preinduction intrathecal morphine and successful intraoperative extubation in OPCAB patients.
Main Methods:
- Retrospective chart review of 112 patients undergoing OPCAB.
- Analysis of patients who received preinduction intrathecal morphine (mean dose 1.0 mg).
Main Results:
- A 77% intraoperative extubation rate was observed.
- Five patients required postoperative naloxone, primarily for respiratory depression.
Conclusions:
- Preinduction intrathecal morphine is associated with a high intraoperative extubation rate in OPCAB.
- 24-hour respiratory monitoring is crucial for detecting delayed respiratory depression.