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[Trombofilia--current status].

Carlos Sánchez Carpio1, Eduardo Rodi, Pablo Piola

  • 1Departamento de Flebología y Linfología-U.H. de Cirugía N(o) 2--Hospital Nacional de Clinicas Córdoba, Argentina. csanchezcarpio@aol.com

Revista De La Facultad De Ciencias Medicas (Cordoba, Argentina)
|September 16, 2004
PubMed
Summary

Thrombophilia, a tendency for blood clots, affects young adults and can lead to severe post-thrombotic syndrome. Early laboratory testing is crucial for diagnosis and preventive treatment in at-risk patients.

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Area of Science:

  • Vascular Medicine
  • Hematology
  • Clinical Diagnostics

Background:

  • Thrombophilia, characterized by a tendency towards venous thrombosis, frequently affects young individuals and can be recurrent.
  • Major consequences include Pulmonary Thromboembolism and Post-thrombotic Syndrome.

Observation:

  • This study evaluated the prevalence of clotting disorders causing thrombophilia in young patients presenting with severe post-thrombotic syndrome.
  • Six patients under 45 with severe venous return dysfunction and post-thrombotic symptoms were analyzed.

Findings:

  • Laboratory analysis revealed anomalous values in 3 patients.
  • Specific findings included positive results for Protein C and Protein S deficiencies, antiphospholipid antibodies, and hyperhomocysteinemia.

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Implications:

  • Laboratory screening for thrombophilia is recommended in patients under 45 with a first-time thrombosis or recurrent episodes.
  • Early detection and hematology referral enable preventive treatment, potentially avoiding thrombotic complications.