Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Demonstrating time sequence and extent of sustained decrease in native heart ejection fraction after heterotopic

Dinesh A Sivaratnam1, Michael J Kelly, Don Esmore

  • 1Department of Nuclear Medicine, The Alfred Hospital, Melbourne, Victoria, Australia. docdin@bigpond.com

The Journal of Heart and Lung Transplantation : the Official Publication of the International Society for Heart Transplantation
|September 16, 2004
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Analysis of 478 Revision Cases for Cervical Disc Arthroplasty Based on Their Biomechanical Design.

International journal of spine surgery·2026
Same author

Robotic-Assisted Muscle-Preserving (RAMP) Decompression in the Thoracic and Lumbar Spine: A Cadaveric Validation.

Spine·2026
Same author

A Structured Ultrasound-Guided Workflow for Level Identification in Lumbar Spine Surgery.

Spine·2026
Same author

Evaluating the Learning Curve and Surgical Efficacy in the Novel Robotic-Assisted Muscle-Preserving (RAMP) Spinal Decompression.

Global spine journal·2025
Same author

Is Intraoperative Neuromonitoring with SSEPs and EMG Predictable for Postoperative Neurologic Deficit in Posterior Lumbar Fusion Surgery? A Retrospective Cohort Analysis.

Global spine journal·2025
Same author

Feasibility and Accuracy of Robotic-Assisted Navigation for Thoracic Pedicle Screw Placement Using CT-Like 3D-MRI.

Spine·2025

Heterotopic heart transplantation (HHTx) causes a significant, early decrease in native heart ejection fraction (EF). This decline is evident by Day 1 post-transplant and may impact recovery strategies.

Area of Science:

  • Cardiology
  • Transplantation Medicine
  • Cardiac Imaging

Background:

  • Investigating the sustained decrease in native heart ejection fraction (EF) after heterotopic heart transplantation (HHTx).
  • Utilizing gated cardiac blood pool scanning (GCBPS) and transthoracic echocardiography (TTE) for assessment.
  • Addressing the lack of comparative pre- and post-operative studies on native EF changes post-HHTx.

Purpose of the Study:

  • To determine the time sequence and extent of native EF decrease following HHTx.
  • To correlate GCBPS findings with TTE results in HHTx patients.
  • To understand the implications of native EF changes for patient recovery and device management.

Main Methods:

  • Inclusion of 13 HHTx patients with pre- and post-operative GCBPS follow-up.

Related Experiment Videos

  • Performance of post-operative TTE in all included patients.
  • Correlation analysis between GCBPS and TTE findings.

    • Main Results:

    • GCBPS revealed a marked decrease in native EF post-HHTx (21.1% to 10.5%, p < 0.0001).
    • Early post-operative TTE (Day 1) showed signs of native left ventricular dysfunction in 4 of 5 patients.
    • No significant further decline in native EF was observed between early and late post-operative GCBPS.

    Conclusions:

    • A dramatic decrease in native heart EF occurs as early as Day 1 post-HHTx.
    • Dissociation of ventricular contraction is the likely cause of native EF decline.
    • Findings suggest potential clinical implications for left ventricular assist device (LVAD) timing and optimizing ventricular recovery.