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The mutagenicity of dichloroacetaldehyde
Zeitschrift Fur Naturforschung. Section C, Biosciences
|September 1, 1978
Summary
Dichloroacetaldehyde, a presumed insecticide metabolite, is mutagenic. This compound exhibits higher mutagenic potency than the known mutagen dichlorvos in bacterial tests.
Area of Science:
- Environmental toxicology
- Chemical mutagenesis
Background:
- Insecticides like dichlorvos and trichlorphon can form metabolites in the environment.
- Dichloroacetaldehyde is a suspected metabolite of dichlorvos and trichlorphon.
Purpose of the Study:
- To evaluate the mutagenicity of dichloroacetaldehyde.
- To compare its mutagenic potency to dichlorvos.
Main Methods:
- Utilized the Salmonella/microsome mutagenicity test.
- Assessed the mutagenic effects of dichloroacetaldehyde and dichlorvos.
Main Results:
- Dichloroacetaldehyde demonstrated mutagenicity in the Salmonella/microsome assay.
- Its mutagenic potency was found to be greater than that of dichlorvos.
Conclusions:
- Dichloroacetaldehyde is a potent mutagen.
- The bacterial mutagenicity test may primarily detect methylation effects from dichlorvos.