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[Clinical study on effect of tongluo capsule in treating diabetic nephropathy caused chronic renal failure]
Wan-sen Sun1, Xi-li Wu, Cheng-lin Qiao
1Department of Integrated Traditional Chinese and Western Medicine, The Second Hospital of Xi'an Jiaotong University, Xi'an (710004).
Objective:
To observe the therapeutic effect of Tongluo capsule (TLC) in treating diabetic nephropathy (DN) complicated chronic renal failure (CRF), and to explore its mechanism preliminarily.
Methods:
Ninety-seven patients with DN-CRF were randomly divided into the TCM group (n = 50) and the WM group (n = 47) to observe the changes of urinary protein per 24 hrs (UP/24h), renal function, creatinine (Cr), blood urea nitrogen (BUN), blood lipids (TG, TC, HDL-C, LDL-C) and serum transforming growth factor-beta1 (TGF-beta1) before and after treatment.
Results:
After 6 months of treatment, levels of UP/24h, Cr, BUN and TGF-beta1 significantly lowered in both groups (P<0.01), and a better effect was showed in the TCM group in aspects of lowering Cr, BUN and TGF-beta1 (P<0.01). Besides, TLC also showed effect in lowering the serum lipid parameters (P<0.05 or P<0.01).
Conclusion:
Effect of TLC in treating DN-CRF might be through lowering the levels of blood lipids and serum TGF-beta1.
