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Updated: Jul 17, 2026

Nanosponge Tunability in Size and Crosslinking Density
Published on: August 4, 2017
Organic nanoparticles whose size and rigidity are finely tuned by cross-linking the end groups of dendrimers
N Gabriel Lemcoff1, Tighe A Spurlin, Andrew A Gewirth
1Department of Chemistry, University of Illinois at Urbana-Champaign, 600 S. Matthews Avenue, Urbana, IL 61801, USA.
Abstract:
Dendrimers with molecular weights ranging from ca. 2700 to 11 000 and from 16 to 64 homoallyl ether end groups were cross-linked using the Grubbs ring-closing metathesis reaction. A combination of SEC, MALDI-TOF-MS, and AFM were used to characterize the cross-linked nanoparticles. The data suggest a significant decrease in volume with cross-linking and a concomitant increase in rigidity, both of which can be controlled independently with a fair degree of precision.
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