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Blood transfusions in the therapy of a case of prolidase deficiency
E Berardesca1, D Fideli, M Bellosta
1Department of Dermatology, IRCCS Policlinico San Matteo, Italy.
The British Journal of Dermatology
|February 1, 1992
Abstract:
A case is reported of a 15-year-old boy with prolidase deficiency and marked urinary excretion of the iminodipeptide gly-pro. Prolidase activity of erythrocytes against substrate glycyl-proline was deficient, but after blood transfusions this was increased to 15.7% of donor activity and declined to 12% and 3.4% of normal activity after 8 and 45 days, respectively. Urinary iminodipeptide levels following transfusion remained unaltered.