[Testosterone substitution in aging males. Which questions are answered?]

Testosterone effects different organs. Thus, a substitution of testosterone in the case of hormone deficiency seems plausible. By analysing 61 randomized studies, we demonstrated that in men older than 65 years there is an increase in bone mass (but not a decrease in fracture risk), an increase in lean body mass, and an increase in erythropoiesis. Changes in cardiovascular parameters, serum lipids, muscle mass, sexual functions, cognition and mood, however, are not clearly proven. The prostate is not negatively influenced. The lack of clear hazards from testosterone substitution in the aging male does not indicate unrestricted treatment safety. Until all doubts are cleared, each treatment should be carefully documented and monitored.