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Keeping track of pro-B cells: a new model for the effects of IL-7 during B cell development

John G Monroe1, David Allman

  • 1Department of Pathology and Laboratory Medicine, University of Pennsylvania School of Medicine, Philadelphia, PA 19104, USA. monroej@mail.med.upenn.edu

European Journal of Immunology
|September 16, 2004
PubMed

Trophic and instructive models have been invoked to explain how various cytokines influence the survival, proliferation and differentiation of lymphoid progenitors. There is evidence that IL-7 can act in either a trophic or an instructive manner during B and T cell development although its roles in B cell development in the fetus versus the adult mouse and in the mouse versus the human may vary. Here we outline the stages of B cell development and the conventional model of the role of IL-7 in the transitions from pro-B cells to pre-B cells and then to immature B cells. We also discuss the implications of recent data that have led to a new model for this process.

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