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Updated: Aug 22, 2026

Utilizing Murine Inducible Telomerase Alleles in the Studies of Tissue Degeneration/Regeneration and Cancer
08:34

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Published on: April 13, 2015

Telomeres and telomerase: a dual role in hepatocarcinogenesis

Ande Satyanarayana1, Michael P Manns, K Lenhard Rudolph

  • 1Department of Gastroenterology, Hepatology and Endocrinology, Medical School of Hannover, Hannover, Germany.

Hepatology (Baltimore, Md.)
|September 16, 2004
PubMed

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In eukaryotic DNA replication, a single-stranded DNA fragment remains at the end of a chromosome after the removal of the final primer. This section of DNA cannot be replicated in the same manner as the rest of the strand because there is no 3’ end to which the newly synthesized DNA can attach. This non-replicated fragment results in gradual loss of the chromosomal DNA during each cell duplication. Additionally, it can induce a DNA damage response by enzymes that recognize single-stranded DNA.
Telomeres and Telomerase02:41

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