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Elevated concentration of cerebrospinal fluid tissue transglutaminase in Parkinson's disease indicating apoptosis
Istvan Vermes1, Ernst N H Jansen Steur, Gustav F Jirikowski
1Department of Clinical Chemistry, Medisch Spectrum Twente Hospital Group, Enschede, The Netherlands. i.vermes@ziekenhuis-mst.nl
Abstract:
Tissue transglutaminase (tTG) is activated during the apoptotic cell death cascade and plays a key role in the formation of apoptotic bodies. We found significant elevation of tTG concentration in the cerebrospinal fluid (CSF) of 54 patients with Parkinson's disease (PD) compared with that measured in 34 control subjects, thus showing increased neural cell apoptosis in patients with PD.
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