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Characteristics of COX2 inhibitors questioned
Nature Reviews. Drug Discovery
|September 17, 2004
Abstract
No abstract available in PubMed .
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Gastric acid, a potent cocktail of hydrogen and chloride ions, is produced in specialized parietal cells within the...
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The concept of therapeutic equivalence (TE) in drugs with multiple indications is complex. A generic drug may be therapeutically equivalent to a brand-name product for one specific indication, but this doesn't necessarily mean it's equivalent for all other indications. Evidence of TE in one patient group and bioequivalence shown in healthy volunteers can support—but not confirm—TE for other indications. However, definitive proof requires individual clinical studies for each indication due to...