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Updated: Aug 22, 2026

Mouse Naïve CD4+ T Cell Isolation and In vitro Differentiation into T Cell Subsets
Published on: April 16, 2015
Feed-forward and feedback mechanisms in a dynamic model of human T cell development and regulation
Michael E Brandt1, Gerhard R F Krueger, Guanyu Wang
1Center for Computational Biomedicine, University of Texas Health Science Center at Houston - SHIS, Houston, Texas 77030, USA. mbrandt@uth.tmc.edu
Abstract:
We describe a computational model of human T cell regulatory dynamics. We used this model to simulate changes in T cell pool numbers and for studying feedback and feed-forward responses in and among these pools. The pools identified were the bone marrow stem cell compartment, early and late thymocyte compartments and the peripheral compartment of mature T lymphocytes. Simulated data showed variable intercompartmental strengths indicative of a range of sensitivities to feedback regulation and respective variable feed-forward responses. The results compare well to known clinical and experimental data, rendering the computational model a good basis for further research in T cell development and regulation.
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