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Updated: Jul 29, 2026
High-throughput and Comprehensive Drug Surveillance Using Multisegment Injection-Capillary Electrophoresis-Mass Spectrometry
Published on: April 23, 2019
[Use of MBDS as a tool for the detection of drug-related adverse events]
S Corral Baena1, M D Guerrero Aznar, M Beltrán García
1Servicio de Farmacia, Hospital Universitario Virgen Macarena, Sevilla. susana.corral@terra.es
Objective:
To analyze drug-related adverse events (DRAE) as noted in hospital discharge reports, as well as their severity and drugs involved, and to assess potential avoidability.
Material And Methods:
A retrospective study for the September-December 2002 period of time in which patients with discharge reports including an ICD-9-CM code E930-E949.9 were selected using the minimum basic data set (MBDS).
Results:
DRAEs were detected in 2.15% of all discharge reports, and 229 were retrospectively assessed. In all, 62.45% (n = 143) were DRAEs detected at the Emergency Department, and 37.55% (n = 86) were DRAEs detected during hospitalization. Of these, 57.20% are considered potentially avoidable. Drugs most commonly involved in the outpatient DRAE sample studied included: digoxin (24.47%, avoidable 97.14%) and NSAIDs-opioids (13.98%, avoidable 75%). Inpatient DRAEs included: anticoagulants (30.23%, avoidable 57.69%) and antimicrobials (17.44%, avoidable 26.67%).
Conclusions:
The study revealed a high proportion of preventable DRAEs around a small number of drugs. Information to prescribing doctors and procedures for treatment follow-up using a unit dose drug dispensing system may be useful to reduce this.
Insights
A study found that over half of drug-related adverse events (DRAEs) were preventable. Key culprits included digoxin, NSAIDs-opioids, anticoagulants, and antimicrobials, highlighting the need for better prescribing practices and drug dispensing systems.
Area of Science:
- Pharmacovigilance and Drug Safety
- Health Services Research
- Clinical Pharmacy
Context:
- Drug-related adverse events (DRAEs) pose a significant challenge in healthcare settings.
- Hospital discharge reports provide valuable data for analyzing patient safety events.
- Understanding the patterns and avoidability of DRAEs is crucial for improving patient outcomes.
Purpose:
- To analyze drug-related adverse events (DRAEs) from hospital discharge reports.
- To determine the severity and identify specific drugs involved in DRAEs.
- To assess the potential avoidability of these adverse events.
Summary:
- A retrospective analysis of 229 DRAEs from hospital discharge reports (September-December 2002) revealed that 57.20% were potentially avoidable.
- Outpatient DRAEs were most commonly associated with digoxin and NSAIDs-opioids, with high avoidability rates (97.14% and 75%, respectively).
- Inpatient DRAEs frequently involved anticoagulants and antimicrobials, with avoidability rates of 57.69% and 26.67%, respectively.
Impact:
- The findings underscore a high proportion of preventable DRAEs linked to a limited number of medications.
- Implementing targeted educational interventions for prescribers and optimizing drug dispensing systems are recommended strategies.
- This research can inform policy and practice to enhance medication safety and reduce healthcare-associated harm.
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