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Evaluation of alternative calculation methods for determining low-density lipoprotein cholesterol in hemodialysis
Eleni T Bairaktari1, Christos Tzallas, M Kalientzidou
1Laboratory of Biochemistry, University Hospital, Medical School, University of Ioannina, 451 10, Ioannina, Greece. ebairakt@cc.uoi.gr
Objectives:
To evaluate alternative equations for the estimation of low-density lipoprotein cholesterol (LDL-C) than the Friedewald equation in hemodialysis patients.
Design And Methods:
The equations LDL-C = 0.41TC - 0.14TG + 0.66ApoB - 10.43 and LDL-C = 0.94TC - 0.94HDL-C - 0.19TG were evaluated in 86 patients and compared with the Friedewald equation and the ultracentrifugation procedure.
Results:
The alternative equations yield significantly lower bias than the Friedewald equation and are less affected by increased triglycerides (TG) levels.
Conclusion:
The alternative equations for LDL-C yield slightly better results than the Friedewald equation especially in hypertriglyceridemia.
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