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Effect of cigarette smoking on serum alpha-tocopherol and the lipid profile in a Portuguese population
Paula A Lopes1, Maria C Santos, Luís Vicente
1Centro de Biologia Ambiental and Departamento de Biologia Animal, Faculdade de Ciências, Universidade de Lisboa, Campo Grande, Bloco C2, 3 piso, 1749-016 Lisboa, Portugal.
Background:
The present study was conducted to determine the effects of cigarette smoking on the levels of serum alpha-tocopherol and on the lipid profile in humans from the Lisbon population.
Methods:
Serum alpha-tocopherol was evaluated by a reverse-phase HPLC method with UV detection. Enzymatic tests were used for the evaluation of the lipid profile.
Results:
Smokers in general and female smokers in particular had decreased alpha-tocopherol levels when compared with nonsmokers. Smokers had also lower HDL cholesterol (HDL-C) contents, but this difference was statistically significant only for females. Regardless of sex, in smokers, there was a positive correlation between alpha-tocopherol and triglyceride (TG) levels. Cluster analysis showed a sex-independent separation between smokers and nonsmokers.
Conclusion:
These results suggest a different interaction of these blood parameters in smokers versus nonsmokers that should be further investigated.
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