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Community-based study in Taiwan aborigines concerning renal dysfunction in gout patients
S J Chang1, C J Chen, H P Hung
1Department of Public Health, School of Medicine, Kaohsiung Medical University, Taiwan.
Objective:
To reveal the factors associated with renal dysfunction among gout patients in Taiwan aborigines.
Methods:
Social demographic data, alcohol consumption data, anthropometric measurements, blood samples, and 24-h urine samples were collected from 128 aboriginals (101 men, 27 women) suffering from gout.
Results:
The men displayed higher mean creatinine clearance (Ccr) values than women. Twenty-two post-menopausal women had significantly lower Ccr values compared to the five pre-menopausal women [probability (p)<0.001]. The males displayed higher 24-h urinary creatinine value than females (8.60+/-5.39 versus 5.58+/-2.14 mmol/L; p<0.05), and showed a significantly higher positive relationship between 24-h urinary creatinine and uric acid excretion [correlation coefficient (r)=0.7304; p<0.001], whereas the females did not (r=0.1144; p=0.5691). Overall, those who were older members of the Tsou tribe, or had excreted less uric acid from urine in 24 h tended to suffer renal dysfunction.
Conclusions:
Gout patients displayed diversity in renal function. An exogenous source of creatinine in men was more likely than in women.