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Updated: Aug 22, 2026
Biosensor-based High Throughput Biopanning and Bioinformatics Analysis Strategy for the Global Validation of Drug-protein Interactions
Published on: December 1, 2020
CO sniffing through heme-based sensor proteins
Paolo Ascenzi1, Alessio Bocedi, Livia Leoni
1Department of Biology and the Interdepartmental Laboratory for Electron Microscopy University Roma Tre, Viale G. Marconi 446, I-00146 Rome, Italy. ascenzi@bio.uniroma3.it
Abstract:
O(2), NO, and CO are substrates, products, and/or modulators in many enzymatic reactions including O(2) respiration, denitrification, N(2) fixation, and methanogenesis. Over the last decade, O(2), NO, and CO have been reported to act as signaling molecules in the control of several distinct biological functions. Here, the heme-based mechanisms of CO sensing by the bacterial homodimeric CooA and the mammalian heterodimeric NPAS2-BMAL1 transcriptional factors are reviewed, and the signal transduction pathways are discussed.
