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Updated: Aug 22, 2026
Induction of Acute Skeletal Muscle Regeneration by Cardiotoxin Injection
Published on: January 1, 2017
Histochemical characterization of skeletal muscles in rats with photochemically-induced stroke
Masahiro Abo1, Satoshi Miyano, Sang Soo Eun
1Department of Rehabilitation Medicine, Jikei Medical School of Medicine, 3-25-8 Nishishinbashi Minato-ku, Tokyo, 105-8461, Japan. abo@jikei.ac.jp
Primary Objective:
The aim of this study was to assess skeletal muscle showing a complete functional recovery after induction of pan-necrotic lesions in the right sensorimotor cortex in rats.
Research Design And Methods:
A focal lesion of the right sensorimotor cortex was induced photochemically. Rats were divided into three groups; the sham-operated group (CON), Stroke (RB) and Stroke plus severed right sciatic nerve (RBD).
Main Outcomes And Results:
All RB rats showed complete functional recovery in the beam-walking test within 10 days. The score of CON rats was 7 for 21 days. The wet weight of the soleus muscle (SOL) only in the RB and RBD was significantly greater than in the CON. The cross-sectional area of type I fibres was increased in SOL.
Conclusions:
It was concluded that the functional recovery was mainly due to increased wet weight and cross-sectional area of type I SOL fibres, which probably reflected the functional reorganization and neuromodulation in the non-damaged contralateral sensorimotor cortex and ipsilateral sensorimotor cortex lateral to the lesion identified in a previous study.
