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PLGA Nanoparticles Formed by Single- or Double-emulsion with Vitamin E-TPGS
Published on: December 27, 2013
Poly (lactide-co-glycolide) nanoparticles containing coumarin-6 for suppository delivery: in vitro release profile
J G Eley1, V D Pujari, J McLane
1Department of Pharmaceutical Sciences School of Pharmacy, Palm Beach Atlantic University, West Palm Beach, Florida 33416, USA. john_eley@pba.edu
Abstract:
A delivery system consisting of the lipophilic fluorescent dye coumarin-6 embedded into polymer nanoparticles in a suppository base was formulated. Particle diameters of 400-1100 nm were produced by a salting-out method and measured by laser diffraction. Nanoparticles reach the systemic circulation via fenestrated capillaries or remain within rectal membranes to release their contents. Dissolution over 168 hr was initially rapid followed by a steady decline, and tissue distribution showed coumarin-6 to be present in liver and lungs for a similar time period while in kidney, small intestines, and blood up to 96 hr. Microscopic observations showed nanoparticles to be present in blood up to 72 hr.
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