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Updated: Aug 22, 2026

Induction of Hypoxia in Living Frog and Zebrafish Embryos
Published on: June 26, 2017
The biology of hypoxia: the role of oxygen sensing in development, normal function, and disease
Amato J Giaccia1, M Celeste Simon, Randall Johnson
1Department of Radiation Oncology, Stanford University School of Medicine, Stanford, California 94305, USA. giaccia@stanford.edu
Abstract:
The ability to sense and respond to changes in oxygen is essential for the survival of prokaryotic and eukaryotic organisms. Oxygen-sensing mechanisms have been developed to maintain cell and tissue homeostasis, as well as to adapt to the chronic low-oxygen conditions found in diseases such as cancer. This report on the first Keystone Meeting on the Biology of Hypoxia will summarize our current understanding of key genes and pathways involved in oxygen sensing that are required for normal development and that are dysregulated in disease states. It will also comment on future directions for this exciting field.
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