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Effects of cholinergic drugs on ureteral function in anesthetized dogs
Yoshitaka Tomiyama1, Isao Wanajo, Yoshinobu Yamazaki
1Pharmacology Research and Development, Kissei Pharmaceutical Co., Ltd., Nagano, Japan. yoshitakatomiyama@pharm.kissei.co.jp
Purpose:
We evaluated the effects of the nonselective muscarinic receptor agonist carbachol (CCh) and its antagonist atropine on ureteral function in anesthetized dogs.
Materials And Methods:
Drug effects were evaluated on elevated pressure in a completely obstructed ureter and peristalsis in its partially obstructed fellow ureters as well as on intravesical isovolumetric pressure.
Results:
CCh (0.1 to 1.0 microg/kg intravenously) dose dependently decreased elevated pressure and peristalsis in completely and partially obstructed ureters, respectively, and increased intravesical isovolumetric pressure. On the other hand, atropine (0.1 to 1.0 mg/kg intravenously) had no significant effects on these 3 variables. Prior administration of atropine (1.0 mg/kg intravenously) completely inhibited the described CCh induced effects.
Conclusions:
Our results demonstrate that in anesthetized dogs cholinergic receptor stimulation has a suppressive effect on ureteral pressure and peristalsis in obstructed ureters, in contrast to its activation of bladder smooth muscle.
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