Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Leprosy and the peripheral nervous system: basic and clinical aspects.

Winnie W Ooi1, Jayashri Srinivasan

  • 1Department of Infectious Disease, Lahey Clinic, 41 Mall Road, Burlington, Massachusetts 01805, USA. winnie.w.ooi@lahey.org

Muscle & Nerve
|September 17, 2004
PubMed
Summary

Leprosy, caused by Mycobacterium leprae, is a leading cause of peripheral neuropathy. Early diagnosis and treatment are crucial for preventing nerve damage and achieving global eradication goals.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

A validation study of mentees' views of mentors' cultural diversity awareness behaviors (CDA race/ethnicity behaviors scale).

Journal of clinical and translational science·2026
Same author

Examining Undergraduates' Intentions to Pursue a Science Career: A Longitudinal Study of a National Biomedical Training Initiative.

Education sciences·2025
Same author

Psychometric Properties of the Science Self-Efficacy Scale for STEMM Undergraduates.

European journal of investigation in health, psychology and education·2025
Same author

Cancer and benign tumors in myotonic dystrophy, facioscapulohumeral muscular dystrophy, and oculopharyngeal muscular dystrophy: a 23-year, single-center, retrospective study.

Acta myologica : myopathies and cardiomyopathies : official journal of the Mediterranean Society of Myology·2025
Same author

Impact of Marine Microplastics on Neurologic and Functional Disabilities: A Population-Level Study.

European journal of neurology·2025
Same author

Evaluating a National Biomedical Training Program Using QuantCrit: Revealing Disparities in Research Self-efficacy for Women of Color Undergraduates.

CBE life sciences education·2024

Area of Science:

  • Neurology
  • Infectious Diseases
  • Microbiology

Background:

  • Leprosy is a significant cause of nontraumatic peripheral neuropathy globally.
  • Mycobacterium leprae targets Schwann cells, leading to nerve damage.
  • Diagnosis relies on skin lesions, neuropathy, and bacilli detection, though pure neuritic leprosy exists.

Purpose of the Study:

  • To review the clinical presentation, diagnosis, and management of leprosy.
  • To highlight the role of electrodiagnostic studies in leprosy.
  • To discuss advances in understanding leprosy pathogenesis and potential eradication strategies.

Main Methods:

  • Review of clinical manifestations and diagnostic features of leprosy.
  • Analysis of electrodiagnostic findings in demyelinating and axonal damage.

Related Experiment Videos

  • Discussion of nerve biopsy utility and molecular advancements.

    • Main Results:

    • Leprosy causes demyelination and axonal damage, detectable by electrodiagnostics.
    • Electrodiagnostic studies aid in monitoring therapy-induced neuropathy.
    • Nerve biopsy can be crucial for diagnosis in challenging cases.

    Conclusions:

    • Leprosy presents with diverse neurological manifestations requiring accurate diagnosis.
    • Electrodiagnostic studies are vital for assessing nerve damage and treatment toxicity.
    • Advances in molecular biology offer hope for improved leprosy prevention and eradication.