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Cells can use their transferrin receptors for locomotion
1MRC, Laboratory of Molecular Biology, Cambridge, UK.
Cells of the B lymphoblastoid cell line JY attach to substrata made of antibodies to the transferrin receptor. Many of these attached cells migrate considerable distances. JY cells also attach to an anti-integrin substratum (anti LFA-1), but on this surface they do not migrate. These results suggest that a circulating receptor--the transferrin receptor--can be used for locomotory purposes, whereas LFA-1, which is not endocytosed in these cells, cannot be used for locomotion. This indicates that the endocytotic cycle can drive cell locomotion.
Cells of the B lymphoblastoid cell line JY attach to substrata made of antibodies to the transferrin receptor. Many of these attached cells migrate considerable distances. JY cells also attach to an anti-integrin substratum (anti LFA-1), but on this surface they do not migrate. These results suggest that a circulating receptor--the transferrin receptor--can be used for locomotory purposes, whereas LFA-1, which is not endocytosed in these cells, cannot be used for locomotion. This indicates that the endocytotic cycle can drive cell locomotion.