A review of the Knops blood group: separating fact from fallacy

It has been more than 10 years since the topic of "high-titer, low-avidity" (HTLA) antibodies was reviewed in Immunohematology. We have learned a lot about these antibodies in the past 10 years and that knowledge has helped us to understand some of the unusual characteristics of these antibodies. Furthermore, it has helped us to name and delineate the various associated blood group systems. Although we will begin with a general review of HTLAs, this manuscript will focus on the recent findings in the Knops blood group system.