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Related Experiment Videos

Dehydroepiandrosterone (DHEA) and aging.

Z Barrou1, P Charru, C Lidy

  • 1Centre de Gérontologie, Hôpital Fernand Widal, 200 Rue du Faubourg Saint-Denis, 75475 Paris, Cedex 10, France.

Archives of Gerontology and Geriatrics
|May 1, 1997
PubMed
Summary
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Dehydroepiandrosterone sulfate (DHEAS) is a common hormone that declines with age. Research suggests DHEA may prevent age-related diseases, but human studies on its effects are limited and require further confirmation.

Area of Science:

  • Endocrinology
  • Gerontology
  • Metabolic Research

Background:

  • Dehydroepiandrosterone sulfate (DHEAS) is the most abundant human steroid hormone, convertible to dehydroepiandrosterone (DHEA).
  • A biological function for DHEAS and DHEA remains undefined.
  • DHEA's age-related decline and potential preventive effects on diseases like heart disease, cognitive impairment, and osteoporosis are noted in human epidemiological and animal studies.

Purpose of the Study:

  • To investigate the biological function of DHEAS and DHEA.
  • To evaluate the effects of oral DHEA supplementation in humans, particularly concerning age-related diseases.
  • To assess the translatability of animal study findings on DHEA to human physiology.

Main Methods:

  • Review of epidemiological studies in humans.

Related Experiment Videos

  • Analysis of animal studies on DHEA's protective effects.
  • Examination of limited human studies on oral DHEA supplementation, focusing on metabolic effects.

    • Main Results:

    • Human epidemiological and animal studies suggest DHEA may prevent age-related illnesses.
    • Adrenal DHEA secretion is primate-specific, limiting direct extrapolation from animal models.
    • Human studies on oral DHEA supplementation show no significant side-effects or changes in body weight, but yield conflicting results on body composition and lipids, with no effect on insulin tolerance. One study indicated improved well-being, requiring confirmation.

    Conclusions:

    • The precise biological function of DHEAS and DHEA requires further elucidation.
    • While animal studies suggest benefits, the effects of DHEA supplementation in humans, particularly for age-related diseases, are not well-established.
    • Further rigorous clinical trials are necessary to confirm the potential benefits of DHEA supplementation on well-being and other age-related conditions in humans.