Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Videos

Reducing equivalents in the aging process.

R Kohen1, D Fanberstein, O Tirosh

  • 1Department of Pharmaceutics, School of Pharmacy, The Hebrew University of Jerusalem, P.O. Box 12065, Jerusalem 91120, Israel. Ronko@cc.huji.ac.il

Archives of Gerontology and Geriatrics
|March 1, 1997
PubMed
Summary
This summary is machine-generated.

Related Concept Videos

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Assessing adherence to objective disease monitoring and outcomes with adalimumab in a real-world IBD cohort.

Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·2021
Same author

A balance and proprioception intervention programme to enhance combat performance in military personnel.

Journal of the Royal Army Medical Corps·2017
Same author

The timing of caffeic acid treatment with cisplatin determines sensitization or resistance of ovarian carcinoma cell lines.

Redox biology·2016
Same author

Correspondence.

Redox report : communications in free radical research·2016
Same author

Low protein and high-energy diet: a possible natural cause of fatty liver hemorrhagic syndrome in caged White Leghorn laying hens.

Poultry science·2016
Same author

Does Wearing Textured Insoles during Non-class Time Improve Proprioception in Professional Dancers?

International journal of sports medicine·2015
Same journal

Corrigendum to "Loneliness trajectories and long-term frailty in the english longitudinal study of ageing: The mediating role of depression". Archives of Gerontology and Geriatrics 2026Jul:146:106210.

Archives of gerontology and geriatrics·2026
Same journal

Corrigendum to "Updating knowledge on existing approaches on advanced care planning interventions: An umbrella review" [Archives of Gerontology and Geriatrics 148 (2026) 106255].

Archives of gerontology and geriatrics·2026
Same journal

Exercise-responsive Wnt/β-catenin signaling across metabolic tissues during aging: A narrative review.

Archives of gerontology and geriatrics·2026
Same journal

Attention as a potentially responsive cognitive outcome in a community-based multidomain dementia prevention program (the community-adapted J-MINT Brain Health Program in Kikuyo Town, Japan).

Archives of gerontology and geriatrics·2026
Same journal

Trajectories of physical function during a 12-week resident-led health promotion program (HATSURATSU) among community-dwelling older adults in Japan.

Archives of gerontology and geriatrics·2026
Same journal

Acute confusional states and functional recovery after West Nile virus infection in hospitalized older adults.

Archives of gerontology and geriatrics·2026
See all related articles

Reducing equivalents, vital for cellular redox balance, decline with age, impacting antioxidant activity. This study reveals their changing levels in rat tissues, offering insights into the aging process.

Area of Science:

  • Biochemistry
  • Gerontology
  • Cellular Biology

Background:

  • Reducing equivalents are crucial for maintaining cellular redox potential and scavenging reactive oxygen species.
  • These molecules, including glutathione and NADH, are synthesized endogenously, while others like ascorbic acid are diet-derived.
  • Their role in the aging process and tissue-specific changes are not fully understood.

Purpose of the Study:

  • To investigate the role of reducing equivalents in the aging process across various rat tissues.
  • To correlate tissue reducing power with antioxidant activity.
  • To develop and apply methods for evaluating age-related changes in reducing power and oxidation status.

Main Methods:

  • Evaluation of overall reducing power in tissue homogenates and biological fluids using cyclic voltammetry.

Related Experiment Videos

  • Assessment of age-related changes in reducing power in liver, lungs, kidneys, heart, and brain tissues.
  • Development of a non-invasive method to assess skin's oxidation status and antioxidant activity.

    • Main Results:

    • Tissue reducing power generally reflects antioxidant activity.
    • Reducing power exhibited a bell-shaped change with age in liver, lungs, and kidneys, but not in heart or brain.
    • Skin showed high reducing power that significantly decreased with age, with increased organic peroxide accumulation in older skin.

    Conclusions:

    • Reducing equivalents play a significant role in aging, with their levels and activity varying by tissue type.
    • The study supports the free radical hypothesis of aging, particularly concerning oxidative stress in aging skin.
    • The developed non-invasive method offers a new approach to evaluate skin aging and antioxidant status.