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Related Experiment Videos

Plasma thrombomodulin values and hepatorenal function in the elderly.

A Deguchi1, K Ohnishi, S Nakamura

  • 1Oyamada Memorial Spa Hospital, 5538-1, Yamada, Yokkaichi, Mie 510-11, Japan.

Archives of Gerontology and Geriatrics
|January 1, 1997
PubMed
Summary

Plasma thrombomodulin (TM) is elevated in elderly individuals and patients with cerebral infarction or diabetes mellitus. Higher TM levels correlate with reduced renal plasma flow and may indicate endothelial injury.

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Area of Science:

  • Biochemistry
  • Gerontology
  • Vascular Medicine

Background:

  • Plasma thrombomodulin (TM) is a crucial protein involved in regulating coagulation and inflammation.
  • Age-related changes in vascular function and potential links to endothelial dysfunction are areas of active research.
  • Understanding biomarkers for vascular health is important for managing age-related diseases and complications.

Purpose of the Study:

  • To investigate the clinical significance of plasma thrombomodulin (TM) levels in elderly individuals.
  • To examine the relationship between plasma TM, renal plasma flow (ERPF), and liver protein synthesis.
  • To assess plasma TM as a potential marker for endothelial injury in various clinical conditions.

Main Methods:

  • Plasma TM levels were measured in healthy young subjects, healthy elderly subjects, and patients with cerebral infarction sequelae.

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  • Correlation analysis was performed between plasma TM, effective renal plasma flow (ERPF), and serum cholinesterase.
  • Plasma TM levels were compared between patients with and without diabetes mellitus (DM), and between DM patients with and without retinopathy.

    • Main Results:

    • Healthy elderly subjects exhibited higher plasma TM levels compared to healthy young subjects.
    • An inverse correlation was observed between plasma TM values and ERPF, suggesting a link to renal arteriosclerosis.
    • Elevated plasma TM was found in patients with cerebral infarction and in patients with diabetes mellitus, particularly those with retinopathy.

    Conclusions:

    • Plasma thrombomodulin (TM) levels increase with age and may be associated with renal arteriosclerosis and impaired liver protein production.
    • Elevated plasma TM in patients with cerebral infarction suggests persistent angiopathy.
    • Increased plasma TM in diabetes mellitus patients, especially with retinopathy, indicates a role in diabetic angiopathy and endothelial injury.