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Related Experiment Videos

Aging and the liver: functional aspects.

K Kitani1

  • 1Radioisotope Research Institute, Faculty of Medicine, University of Tokyo, 7-3-1, Hongo, Bunkyo-ku, Tokyo 113, Japan.

Archives of Gerontology and Geriatrics
|September 1, 1994
PubMed
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Liver aging in male rats shows feminization and functional decline, unlike females and mice. Antioxidant enzyme activity, like catalase, can increase with age, challenging general aging theories.

Area of Science:

  • Gerontology
  • Hepatology
  • Biochemistry

Background:

  • Aging significantly impacts liver function, particularly the hepatic microsomal cytochrome monooxygenase system in male rats.
  • This decline is linked to liver feminization in aging males, contrasting with stable function in females and mice.
  • Phase II reactions and Glutathione S-transferase (GST) activities also exhibit age-related changes, with GST showing sensitivity to dietary manipulation.

Purpose of the Study:

  • To critically review 30 years of Japanese research on liver aging, focusing on functional aspects.
  • To evaluate the clinical implications of liver aging studies.
  • To examine the impact of aging on liver enzyme systems and cellular processes.

Main Methods:

  • Analysis of hepatic microsomal cytochrome monooxygenase system and Phase II reactions in aging male and female rats, and mice.

Related Experiment Videos

  • Assessment of Glutathione S-transferase (GST) enzyme activities under varying dietary conditions.
  • Application of fluorescence recovery after photobleaching (FRAP) to study protein lateral mobility in hepatocyte membranes.
  • Validation of the protease inhibitor model of aging in hepatocytes using leupeptin infusion.

    • Main Results:

    • Male rat livers exhibit feminization with aging, leading to a decline in cytochrome monooxygenase activity.
    • Female rat and mouse livers show stable function of this system with age.
    • Catalase (CAT) activity increases with age in female rat livers, while superoxide dismutase (SOD) remains generally stable.
    • Age-dependent decline in hepatocyte surface membrane protein mobility and accumulation of lipofuscin-like granules were observed.

    Conclusions:

    • Liver aging is complex, with sex-specific differences in functional decline.
    • The aging process in hepatocytes involves changes in membrane dynamics and potential accumulation of cellular damage markers.
    • Antioxidant enzyme activity can increase with age, questioning generalized theories of age-related functional decline.