Related Experiment Video
Updated: Jul 10, 2026
10:13
Assessment of Age-related Changes in Cognitive Functions Using EmoCogMeter, a Novel Tablet-computer Based Approach
Published on: February 14, 2014
Brain monoamine oxidase and aging: a review
S G Burchinsky1, S M Kuznetsova
1Institute of Gerontology, USSR Academy of Medical Sciences, Vyshgorodskaya 67, 252655 Kiev-114, USSR.
Archives of Gerontology and Geriatrics
|January 1, 1992
Summary
Research on brain monoamine oxidase (MAO) activity in aging reveals its role in age-related diseases. Deprenyl, an MAO-B inhibitor, shows promise for treating parkinsonism and aging in geriatric practice.
Area of Science:
- Neuroscience
- Gerontology
- Pharmacology
Background:
- Age-related changes in brain monoamine oxidase (MAO) activity are linked to neurodegenerative pathologies.
- MAO plays a critical role in the pathogenesis of parkinsonism.
- 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) is implicated in aging-related parkinsonism.
Purpose of the Study:
- To review current research on age-related MAO dynamics.
- To elucidate MAO's role in aging and parkinsonism.
- To analyze the efficacy and mechanisms of deprenyl in aged individuals.
Main Methods:
- Literature review of studies on MAO activity and aging.
- Analysis of MAO's interaction with MPTP in parkinsonism.
- Examination of deprenyl's mechanism of action in geriatric contexts.
Main Results:
- MAO activity exhibits significant age-related dynamics.
- MAO is a key factor in the development of parkinsonism.
- Deprenyl, a selective MAO-B inhibitor, demonstrates efficacy in aged subjects.
Conclusions:
- Deprenyl is effective for treating parkinsonism in the elderly.
- Deprenyl may act as a geroprotector, offering benefits beyond parkinsonism treatment.
- Geriatric practice can benefit from the use of deprenyl.
More Related Videos
Related Concept Videos
01:37Mitochondria
Mitochondria are eukaryotic cellular organelles that are known to produce energy through a process called oxidative phosphorylation. Besides their primary function, mitochondria are involved in various cellular processes, including cell growth, differentiation, signaling, metabolism, and senescence. Age-related changes cause a decline in mitochondrial quality and integrity due to increased mitochondrial mutations and oxidative damage. Thus, aging can severely impact mitochondrial functions,...
01:26Alzheimer's Disease: Overview
Alzheimer's Disease (AD) is a continually advancing neurodegenerative disorder, distinguished by escalating memory loss, cognitive dysfunction, and dementia. The disease unfolds in three stages: preclinical, mild cognitive impairment (MCI), and dementia. Its onset is insidious, and the progression gradual, with the cause not well explained by other disorders.
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
The clinical diagnosis of AD hinges on the presence of memory and other cognitive impairments. Biomarkers, such as changes in Aβ and tau...
01:18Pharmacokinetics in Geriatric Patients: Effect of Age on Drug Metabolism
Geriatric patients show significant variation in how their bodies process medications, which can change how effective and safe treatments are. The liver is the primary organ where drug metabolism occurs, involving two main types of chemical reactions: phase I and II. Phase I metabolism is driven by the cytochrome P450 enzyme system, which includes key types such as CYP3A, CYP2D6, and CYP2C9. Research indicates that while aging doesn't notably alter the levels or activity of these enzymes, it...
01:27Pharmacodynamics in Geriatric Patients: Effects of Age
Age-related pharmacokinetic changes are extensively documented, but understanding age-related pharmacodynamic alterations is relatively limited. This knowledge gap can be partly attributed to the complexity of developing appropriate measures of drug responses compared to bioanalytical methods for determining drug concentrations.Most information regarding age-related differences in human pharmacodynamics originates from cross-sectional studies. However, these studies assume that observed mean...
01:26Aging
Aging is a complex biological phenomenon influenced by various processes that affect cellular and systemic functions. Several prominent theories attempt to explain its mechanisms, highlighting cellular limitations, oxidative damage, and hormonal changes as central factors in aging.
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
Cellular Clock Theory
The cellular clock theory posits that the human lifespan is closely tied to the finite capacity of cells to divide, a phenomenon governed by telomeres, which are protective caps at the ends of...
01:29Alzheimer Disease l: Introduction
Alzheimer disease is a chronic, progressive, and irreversible neurodegenerative disorder and the most common cause of dementia in older adults. It leads to gradual neuronal loss, causing cognitive decline, behavioral changes, and loss of functional independence.Risk Factors and EtiologyThe disease is multifactorial. Age is the strongest risk factor, with prevalence doubling every 5 years after age 65. Genetic factors include mutations in genes such as APP, PSEN1, and PSEN2, which are associated...