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Related Experiment Videos

Universal constraint on evolution of all coding sequences.

S Ohno1

  • 1Beckman Research Institute of the City of Hope, Duarte, CA 91010-0269, U.S.A.

Archives of Gerontology and Geriatrics
|January 1, 1992
PubMed
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Natural selection in evolution faces a paradox: protein function arises intrinsically from coding sequences, not selection. A universal rule, the TA/CG-deficiency-TG/CT-excess rule, governs sequence construction, influencing amino acid composition.

Area of Science:

  • Evolutionary biology
  • Molecular biology
  • Genetics

Background:

  • Natural selection paradox in evolution.
  • Protein function acquisition is intrinsic to coding sequence principles.
  • Similar amino acid compositions across divergent protein functions suggest a universal construction rule.

Purpose of the Study:

  • To explore the inherent paradox of natural selection in evolution.
  • To investigate the universal rule governing coding sequence construction.
  • To understand how sequence composition influences protein function and evolution.

Main Methods:

  • Analysis of coding sequences and amino acid compositions.
  • Examination of base composition rules, specifically the TA/CG-deficiency-TG/CT-excess rule.

Related Experiment Videos

  • Investigation of codon usage and reading frame effects on protein synthesis.

    • Main Results:

    • The TA/CG-deficiency-TG/CT-excess rule is a universal principle in coding sequence construction.
    • This rule leads to C T G being a common base trimer, with Leucine as a major residue.
    • Reading frame selection influences amino acid incorporation, affecting protein composition (e.g., Ala, Pro, Cys).

    Conclusions:

    • Protein function originates from inherent coding sequence properties, not solely from natural selection.
    • The universal rule of sequence construction dictates amino acid composition and influences evolutionary pathways.
    • Understanding these sequence principles is crucial for comprehending protein evolution and function.