Diet restriction, body temperature and physicochemical properties of cell membranes

This paper summarizes some recent results of the effect of diet restriction upon body temperature and membrane microviscosity of lymphocytes, hepatocytes and cerebellar cells of diet-restricted female Wistar rats. The treated animals were fed on an every-other-day schedule starting from the age of 3.5 months. It is suggested that a decrease in average body temperature (-1 degree C) of diet-restricted animals as compared to the ad libitum fed ones may stimulate the cells to synthesize more fluid membranes. Together with these the maintenance of the activity of protective enzymes is another key event which helps to prevent the age-dependent deterioration of cell membrane functions.