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Glucose intolerance in the elderly: an open debate.

G Paolisso¹, M Varricchio, F D'Onofrio

¹Istituto di Gerontologia e Geriatria, Terapia Medica e Malattie del Metabolismo, Università degli Studi di Napoli, Naples, Italy.

Archives of Gerontology and Geriatrics

|September 1, 1990

Summary

Glucose intolerance is common in older adults but its mechanisms remain unclear. Impaired insulin secretion, insulin action, and environmental factors contribute, with multiple issues needed for intolerance to develop.

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Area of Science:

Gerontology
Metabolic Disorders
Physiopathology

Background:

Glucose intolerance is a prevalent condition in the aging population.
The underlying mechanisms contributing to age-related glucose intolerance are not fully understood.
Existing research highlights potential links to insulin secretion and action, as well as environmental influences.

Purpose of the Study:

To review and elucidate the potential mechanisms behind glucose intolerance in aged individuals.
To explore the roles of impaired insulin secretion and insulin action in aging.
To examine the contribution of environmental factors to glucose dysregulation in the elderly.

Main Methods:

Literature review of existing studies on aging and glucose metabolism.
Analysis of physiological and pathological factors affecting glucose handling in older adults.
Synthesis of evidence regarding insulin secretion, insulin action, and environmental impacts.

Main Results:

Impaired insulin secretion and reduced insulin action are identified as key contributors to glucose intolerance in aging.
Environmental factors play a significant role in the development of impaired glucose handling.
Glucose intolerance in aged individuals is often associated with the presence of multiple pathological findings.

Conclusions:

The mechanisms of glucose intolerance in aging involve a combination of intrinsic physiological changes and extrinsic environmental factors.
Not all elderly individuals develop glucose intolerance, suggesting a threshold effect of accumulating pathological conditions.
Understanding these mechanisms is crucial for developing targeted interventions for age-related metabolic dysfunction.