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Updated: Aug 22, 2026

Preparation of Acute Hippocampal Slices from Rats and Transgenic Mice for the Study of Synaptic Alterations during Aging and Amyloid Pathology
Published on: March 23, 2011
Ca2+ regulation and gene expression in normal brain aging
Emil C Toescu1, Alexei Verkhratsky, Philip W Landfield
1Department of Physiology, Division of Medical Sciences, The University of Birmingham, Edgbaston B15 2TT, UK. e.c.toescu@bham.ac.uk <e.c.toescu@bham.ac.uk>
Abstract:
Understanding the cellular mechanisms that characterize the functional changes of the aged brain is an ongoing and formidable challenge for the neuroscience community. Evidence now links changes in Ca(2+) influx and homeostasis with perturbations induced by the aging process in the function of the main intracellular organelles involved in Ca(2+) regulation: the endoplasmic reticulum and mitochondria. New perspectives are also offered by recent gene microarray studies, illustrating the multifactorial nature of the aging process.
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