Usefulness of C-reactive protein and left ventricular function for risk assessment in survivors of acute myocardial

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Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty
10:03

Coronary Progenitor Cells and Soluble Biomarkers in Cardiovascular Prognosis after Coronary Angioplasty

Published on: January 28, 2020

Juan Sanchis1, Vicent Bodí, Angel Llácer

  • 1Hospital Clínic Universitari, Servei de Cardiologia, Blasco Ibáñez 17, València 46010, Spain. sanchis_juafor@gva.es

The American Journal of Cardiology
|September 18, 2004
PubMed

Insights

C-reactive protein (CRP) offers minor additional prognostic value for cardiac death risk in acute myocardial infarction (AMI) survivors. While associated with mortality, its predictive impact is marginal beyond age and ventricular function metrics.

Area of Science:

  • Cardiology
  • Biomarkers
  • Prognostics

Background:

  • Acute myocardial infarction (AMI) survivors require accurate prognostic assessment.
  • Left ventricular function parameters are established predictors of cardiac mortality.
  • The incremental prognostic value of inflammatory markers like C-reactive protein (CRP) remains under investigation.

Purpose of the Study:

  • To investigate the additional prognostic information provided by C-reactive protein (CRP) in survivors of acute myocardial infarction (AMI).
  • To assess CRP's predictive role beyond established parameters of left ventricular function.

Main Methods:

  • Prospective study of 665 AMI survivors (326 ST-elevation, 339 non-ST-elevation).
  • Cox multivariable analysis was used to identify predictors of 6-month cardiac death.
  • Key predictors analyzed included age, Killip class, ejection fraction, and C-reactive protein (CRP) levels.

Main Results:

  • Age, Killip class >I, reduced ejection fraction, and higher CRP levels were significant predictors of 6-month cardiac death.
  • The C-index of the prognostic model was 0.77 without CRP and 0.78 with CRP.
  • CRP demonstrated a statistically significant association with mortality, but its additive predictive value was marginal.

Conclusions:

  • C-reactive protein (CRP) is associated with mortality in AMI survivors, independent of age and ventricular function.
  • The incremental prognostic relevance of CRP in predicting cardiac death appears limited.
  • Further research may clarify the clinical utility of CRP in refining risk stratification for AMI survivors.

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