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MAP-O-MAT: internet-based linkage mapping.

X Kong1, T C Matise

  • 1Department of Genetics, Rutgers University Piscataway NJ 08854, USA.

Bioinformatics (Oxford, England)
|September 18, 2004
PubMed
Summary
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MAP-O-MAT is a web tool for automated linkage mapping of human DNA markers. It verifies marker order and map distances using various genotype datasets and human genome assembly data.

Area of Science:

  • Genetics
  • Bioinformatics

Background:

  • MAP-O-MAT is a web-based server for automated linkage mapping.
  • It utilizes genotype data from CEPH, Marshfield, SNP Consortium, and Rutgers linkage maps.
  • Physical map positions are integrated from the human genome assembly.

Purpose of the Study:

  • To provide a tool for automated linkage mapping of human polymorphic DNA markers.
  • To facilitate the verification of marker order and map distances for custom mapping sets.

Main Methods:

  • The system uses genotype data from multiple established linkage maps.
  • It incorporates the CRI-MAP program for likelihood calculations and mapping algorithms.
  • Physical map positions are derived from the human genome assembly.

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Main Results:

  • MAP-O-MAT enables automated verification of linkage map accuracy.
  • It supports custom mapping sets with diverse genotype data sources.
  • The server integrates linkage and physical mapping information.

Conclusions:

  • MAP-O-MAT offers an automated solution for human DNA marker linkage mapping.
  • The tool enhances the accuracy and efficiency of genetic map construction.
  • It serves as a valuable resource for geneticists and bioinformaticians.