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Acute bovine laminitis: a new induction model using alimentary oligofructose overload
M B Thoefner1, C C Pollitt, A W Van Eps
1Department of Large Animal Sciences, Clinical Institute, Royal Veterinary and Agricultural University of Copenhagen, Denmark. mbt@kvl.dk
Journal of Dairy Science
|September 18, 2004
Summary
Oligofructose overload in dairy heifers induced signs of acute laminitis, including lameness and metabolic acidosis. This study establishes a new model for investigating bovine laminitis pathogenesis.
Area of Science:
- Veterinary Medicine
- Animal Science
- Ruminant Nutrition
Background:
- Oligofructose overload can cause gastrointestinal issues in ruminants.
- Laminitis is a significant concern in cattle, impacting welfare and productivity.
- Understanding the induction of laminitis is crucial for developing preventative strategies.
Purpose of the Study:
- To investigate the clinical response to alimentary oligofructose overload in dairy heifers.
- To establish a novel experimental model for studying bovine laminitis.
Main Methods:
- Twelve dairy heifers were administered varying doses of oligofructose (13, 17, or 21 g/kg) or a sham treatment (tap water).
- Clinical signs including lameness, cardiovascular, and gastrointestinal function were monitored.
- Animals were euthanized at 48 and 72 hours post-administration for further assessment.
Main Results:
- All oligofructose-treated heifers exhibited depression, anorexia, and diarrhea.
- Metabolic acidosis, fever, and dehydration were observed but responsive to supportive care.
- Four out of six heifers developed clinical signs of acute laminitis, characterized by subtle lameness.
Conclusions:
- Alimentary oligofructose overload effectively induces acute laminitis in cattle.
- This model provides a valuable tool for future research into the pathogenesis and pathophysiology of bovine laminitis.